This combination medication is indicated in low blood calcium levels in people who do not get enough calcium from their diets. It may be used to treat conditions caused by deficiency of calcium such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany). Ipriflavone is a synthetic isoflavone which may be used to inhibit bone resorption, maintain bone density and to prevent osteoporosis in postmenopausal women.

Indications:

⇒ Hypoparathyroidism (with bone disease)
⇒ Osteoporosis
⇒ Rickets
⇒ Osteomalacia
⇒ Muscle diseases

Mechanism of action:

Calcium Carbonate is the carbonic salt of calcium (CaCO3). It provides calcium and can be used in conditions like low calcium levels such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and certain muscle disease (latent tetany). Calcium in body is necessary for strong bones, muscle contraction, nervous system, and heart. Calcium carbonate also is used as an antacid to relieve heartburn, acid indigestion, and upset stomach.
Ipriflavone is a synthetic isoflavone. Isoflavones are water-soluble chemicals found in many plants. Ipriflavone would possess the bone-stimulating effects of estrogen without any estrogen-like activity elsewhere in the body. Such a product would help prevent osteoporosis, but cause no other health risks. Ipriflavone combined with calcium can slow and perhaps slightly reverse bone breakdown. It also seems to help reduce the pain of fractures caused by osteoporosis. However, since it does not appear to have any estrogenic effects anywhere else in the body, it shouldn't increase the risk of breast or uterine cancer. On the other hand, it won't reduce the hot flashes, night sweats, mood changes, or vaginal dryness of menopause, nor prevent heart disease.
Alfacalcidol is an active metabolite of Vitamin D helps in regulation of the calcium balance and the bone metabolism. Alfacalcidol is indicated for the management of low calcium level, secondary hyperparathyroidism, and osteodystrophy in patients with chronic renal failure. 25-hydroxylase in the liver activates vitamin D3 and this active form binds to intracellular receptors that then function as transcription factors to modulate gene expression. The vitamin D receptor forms a complex with another intracellular receptor and forms heterodimer which binds to DNA. Absorption of phosphorus and calcium is increased by alfacalcidol, increasing osteoclastic resorption, and increasing distal renal tubular reabsorption of calcium.

Side Effects:

The product is possible safe for most adults. There is no disadvantage associated with the product if taken under the recommended usage however headache, dizziness, nausea, abdominal distention and irregular heartbeat may occur in some patients. If more severe side effects appear, immediately discontinue the use.

Interactions:

The product can interact with the following drugs:
⇒ Tetracycline antibiotics
⇒ Antacids

Contraindication:

⇒ Kidney disease
⇒ Kidney stones
⇒ Heart disease
⇒ Parathyroid gland disorder
⇒ Do not consume alcohol.

Warning & Precaution:

⇒ Do not exceed the recommended dose
⇒ Keep out of reach of children